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Home / 2025 Mercedes-Benz E 350 Sedan vs 2025 Mercedes-Benz E 350 4MATIC® Sedan

2025 Mercedes-Benz E 350 Sedan vs 2025 Mercedes-Benz E 350 4MATIC® Sedan 

Mercedes-Benz sedans perfectly balance luxury, performance, and cutting-edge technology. For 2025, the Mercedes-Benz E 350 Sedan and the E 350 4MATIC® Sedan are exceptional options in the lineup. Both models offer unparalleled refinement, advanced safety features, and thrilling performance, ensuring a remarkable driving experience. However, while they share many similarities, they also cater to distinct driving preferences. The 2025 E 350 Sedan emphasizes comfort and efficiency, while the 2025 E 350 4MATIC® Sedan adds confidence-inspiring all-wheel drive capability for enhanced handling.   


At Mercedes-Benz of Arrowhead in Peoria, AZ, you can explore both models and find the one that perfectly complements your lifestyle.

2025 Mercedes-Benz E 350 Sedan vs 2025 Mercedes-Benz E 350 4MATIC® Sedan

More on Mercedes-Benz E-Class Inventory Reach Out to Us!

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2025 Mercedes-Benz E-Class E 350 4MATIC® Sedan
2025 Mercedes-Benz E-Class E 350 4MATIC® Sedan
$67,310
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2025 Mercedes-Benz E-Class E 350 Sedan
2025 Mercedes-Benz E-Class E 350 Sedan
$67,845
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2025 Mercedes-Benz E-Class E 350 Sedan
2025 Mercedes-Benz E-Class E 350 Sedan
$67,895
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2025 Mercedes-Benz E-Class E 350 RWD Sedan
2025 Mercedes-Benz E-Class E 350 RWD Sedan
$68,605
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2025 Mercedes-Benz E-Class E 350 RWD Sedan
2025 Mercedes-Benz E-Class E 350 RWD Sedan
$69,405
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2025 Mercedes-Benz E-Class E 350 Sedan
2025 Mercedes-Benz E-Class E 350 Sedan
$70,705
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2025 Mercedes-Benz E-Class E 350 Sedan
2025 Mercedes-Benz E-Class E 350 Sedan
$72,655
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2025 Mercedes-Benz E-Class E 350 Sedan
2025 Mercedes-Benz E-Class E 350 Sedan
$72,805
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2025 Mercedes-Benz E-Class E 350 RWD Sedan
2025 Mercedes-Benz E-Class E 350 RWD Sedan
$72,825
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2025 Mercedes-Benz E-Class E 350 RWD Sedan
2025 Mercedes-Benz E-Class E 350 RWD Sedan
$73,415
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2025 Mercedes-Benz E 350 Sedan

Specs

2025 Mercedes-Benz E 350 4MATIC® Sedan

2.0L Inline-4 Turbo Engine with Mild Hybrid Drive and 9G-TRONIC Automatic Transmission 

Engine and Transmission

2.0L Inline-4 Turbo Engine with Mild Hybrid Drive and 9G-TRONIC Automatic Transmission

255 HP and 295 lb-ft of Torque
Power and Torque 255 HP and 295 lb-ft of Torque
0-60 mph in 6.1 sec Acceleration0-60 mph in 6.1 sec
Rear-Wheel Drive Drive Configuration 4MATIC® All-Wheel Drive
25 MPG City and 33 mpg Highway
Fuel Economy 24 MPG City and 33 MPG Highway
5 Passenger Capacity and 12.7 cu ft Cargo Capacity
Passenger Capacity and Cargo Space 5 Passenger Capacity and 12.7 cu ft Cargo capacity


Why Choose the 2025 Mercedes-Benz E 350 Sedan and E 350 4MATIC® Sedan?  

2025 Mercedes-Benz E 350 Sedan  

The 2025 Mercedes-Benz E 350 Sedan offers sophistication with its sleek design, intuitive technology, and luxury-focused interior. Powered by a turbocharged 2.0-liter inline-4 engine, it delivers a robust 255 horsepower, paired with a 9G-TRONIC® automatic transmission for seamless gear shifts. Inside, passengers are treated to premium materials, ambient lighting, and a spacious cabin. Features like the MBUX infotainment system and a digital instrument cluster keep you connected while providing an immersive driving experience.  

The 2025 E 350 Sedan is ideal for drivers prioritizing efficiency, style, and smooth handling. Its rear-wheel-drive setup strikes a balance between performance and fuel economy, making it a standout choice for daily commutes or long-distance travel.  

2025 Mercedes-Benz E 350 Sedan vs 2025 Mercedes-Benz E 350 4MATIC® Sedan

2025 Mercedes-Benz E 350 4MATIC® Sedan  

For drivers seeking more traction and stability, the 2025 Mercedes-Benz E 350 4MATIC® Sedan delivers unmatched confidence. Sharing the same powerful engine and luxury features as the 2025 E 350 Sedan, this model adds the advanced 4MATIC® all-wheel-drive system. Whether navigating wet roads or winding mountain passes, this feature ensures optimal grip and control.  


The interior mirrors the elegance of the E 350 Sedan, with meticulously crafted details and cutting-edge technology. However, the 4MATIC® system’s added capability makes it a versatile option for those who want a luxury sedan that performs effortlessly in all conditions.  

For drivers who typically stick to city streets or highways, the E 350 Sedan offers all the luxury and performance expected of a Mercedes-Benz. However, if you desire extra versatility and the confidence to tackle various terrains, the E 350 4MATIC® Sedan is worth the upgrade.  

2025 Mercedes-Benz E 350 Sedan vs 2025 Mercedes-Benz E 350 4MATIC® Sedan

Key Differences Between the 2025 Mercedes-Benz E 350 Sedan and E 350 4MATIC® Sedan  


The primary difference between these models lies in their drivetrain. The 2025 E 350 Sedan features a rear-wheel-drive system, offering a dynamic and balanced drive. This setup is ideal for drivers who appreciate responsive handling and a lighter overall feel.  


In contrast, the 2025 E 350 4MATIC® Sedan is equipped with the 4MATIC® all-wheel-drive system, which enhances traction and stability in various driving conditions. It also includes the 4-wheel Electronic Traction System (4-ETS), which redistributes torque to individual wheels as needed, ensuring superior grip. This makes the 4MATIC® version particularly appealing for those frequently encountering rain, snow, or uneven terrain.
 

While both models share advanced features such as MBUX voice control, wireless smartphone integration, and driver assistance systems, the E 350 4MATIC® Sedan offers an edge in all-weather capability. Its 4MATIC® system provides peace of mind in challenging environments, while the E 350 Sedan is better suited for drivers who prioritize efficiency and a lighter ride.  

2025 Mercedes-Benz E 350 Sedan and 2025 Mercedes-Benz E 350 4MATIC® Sedan color options

Color Options of the 2025 Mercedes-Benz E 350 Sedan and E 350 4MATIC® Sedan  


  • Black 
  • Polar White  
  • Verde Silver Metallic  
  • Obsidian Black Metallic  
  • Nautical Blue Metallic  
  • Sonoran Brown Metallic  
  • Graphite Grey Metallic 
  • Cirrus Silver Metallic
  • MANUFAKTUR® Alpine Grey
  • MANUFAKTUR® Patagonia Red Metallic
  • MANUFAKTUR® Moonlight White Metallic 

The colors from top to bottom reflect the colors in the adjacent image from left to right.

Test Drive the 2025 Mercedes-Benz E Sedan Models in Peoria, AZ  

Discover the perfect blend of luxury and performance by test-driving the 2025 Mercedes-Benz E 350 Sedan and E 350 4MATIC® Sedan. Each model offers a unique driving experience tailored to your needs, whether you prioritize efficiency, comfort, or all-weather confidence.  


Visit Mercedes-Benz of Arrowhead in Peoria, AZ, to explore these exceptional sedans in person. Our knowledgeable team is here to help you compare features, answer your questions, and find the model that matches your lifestyle. Experience the sophistication and innovation of the 2025 Mercedes-Benz E Sedan lineup today! 

2025 Mercedes-Benz E 350 Sedan vs 2025 Mercedes-Benz E 350 4MATIC® Sedan
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